Fig. 1 · Structure
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JNJ-46356479
mGlu2 Receptor Modulator
JNJ-46356479 is a selective positive allosteric modulator of the mGlu2 receptor, exhibiting an EC50 value of 78 nM. It demonstrates significant in vivo activity, making it a valuable compound for research into neurological disorders. This reagent is suitable for studies focused on enhancing glutamate signaling and understanding its implications in various therapeutic contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1254979-66-2 |
| Applications | mGlu2 Receptor Modulator |
| Formula | C22H22F5N5 |
| Molecular Weight | 451.44 |
| SMILES | FC1=CC=C(C(F)=C1)N2CCN(CC2)CC3=C(C4=NN=C(N4C=C3)CC5CC5)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.