Fig. 1 · Structure
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JNJ-4929821
MetAP-2 Inhibitor
JNJ-4929821 is a selective inhibitor of Methionine aminopeptidase-2 (MetAP-2) with an IC50 value of 15 nM, demonstrating a higher affinity for MetAP-2 compared to MetAP-1. This triazole derivative is of significant interest in cancer research, particularly in the study of liver cancer, colorectal adenocarcinoma, and pancreatic cancer. JNJ-4929821 serves as a valuable tool for investigating the role of MetAP-2 in tumor biology and therapeutic potential.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 836671-12-6 |
| Applications | MetAP-2 Inhibitor |
| Formula | C14H13FN4O2S2 |
| Molecular Weight | 352.41 |
| SMILES | O=S(C1=CC=CS1)(N(CC2=CC=C(F)C=C2)CC3=NC=NN3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.