Fig. 1 · Structure
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JNJ-5207852 dihydrochloride
H3 Receptor Antagonist
JNJ-5207852 dihydrochloride is a highly selective and potent antagonist of the histamine H3 receptor (H3R), displaying pKis of 8.9 and 9.24 for rat and human H3R, respectively. This compound is utilized in research to explore the role of H3R in neurological disorders and to investigate potential therapeutic applications in cognitive enhancement and sleep regulation. Its ability to modulate histaminergic neurotransmission makes it a valuable tool in the study of various central nervous system functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1782228-76-5 |
| Applications | H3 Receptor Antagonist |
| Formula | C20H34Cl2N2O |
| Molecular Weight | 389.40 |
| SMILES | [H]Cl.[H]Cl.N1(CCCOC2=CC=C(CN3CCCCC3)C=C2)CCCCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.