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JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.69 mL | 103.44 mL | 206.88 mL |
| 0.5 mM | 4.14 mL | 20.69 mL | 41.38 mL |
| 1 mM | 2.07 mL | 10.34 mL | 20.69 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
*The above data is based on the productmolecular weight 483.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16861 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 483.37 |
| Formula | C22H23BrN6O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2086772-26-9 |
| Synonyms | JNJ64619178, JNJ 64619178 |
| SMILES | BrC1=C(N)N=C(C=C(CC[[email protected]@H]2[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1 |
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