JNJ-64619178

Catalog No.: A16861

Histone Methyltransferase inhibitor

JNJ-64619178

JNJ-64619178 Chemical Structure

CAS NO. 2086772-26-9

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.

Availability: In stock

Package Price Qty
1 mg
$90.00
2 mg
$140.00
5 mg
$200.00
50 mg
$1,080.00
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Biological Activity

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
In vitro DMSO 94 mg/mL (194.47 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.69 mL 103.44 mL 206.88 mL
0.5 mM 4.14 mL 20.69 mL 41.38 mL
1 mM 2.07 mL 10.34 mL 20.69 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 483.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16861
Actions Inhibitor
CAS No. 2086772-26-9
Formula C22H23BrN6O2
M. Wt 483.37
Purity >98%
Synonyms JNJ64619178, JNJ 64619178
SMILES BrC1=C(N)N=C(C=C(CC[[email protected]@H]2[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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