JNJ-64619178

Catalog No.: A16861

Histone Methyltransferase inhibitor

JNJ-64619178

JNJ-64619178 Chemical Structure

CAS NO. 2086772-26-9

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.

Availability: In stock

Package Price Qty
1 mg
$90.00
2 mg
$140.00
5 mg
$200.00
50 mg
$1,080.00
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Biological Activity

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.69 mL 103.44 mL 206.88 mL
0.5 mM 4.14 mL 20.69 mL 41.38 mL
1 mM 2.07 mL 10.34 mL 20.69 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 483.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16861
Actions Inhibitor
M. Wt 483.37
Formula C22H23BrN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2086772-26-9
Synonyms JNJ64619178, JNJ 64619178
SMILES BrC1=C(N)N=C(C=C(CC[[email protected]@H]2[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1

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