Fig. 1 · Structure
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JNJ-65355394
OGA Inhibitor
JNJ-65355394 is a selective inhibitor of O-GlcNAc hydrolase (OGA), a key enzyme involved in the regulation of O-GlcNAcylation. By inhibiting OGA, this compound enhances O-GlcNAc levels, thereby influencing cellular processes such as signal transduction, transcription, and metabolism. JNJ-65355394 serves as a valuable tool for research in glycosylation dynamics and its implications in various disease states, including cancer and neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2230598-99-7 |
| Applications | OGA Inhibitor |
| Formula | C19H26N4OS |
| Molecular Weight | 358.50 |
| SMILES | CC(NC1=NC=C(S1)CN2C[C@H](CCC2)CC3=CC(C)=NC(C)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.