Fig. 1 · Structure
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JNJ-78911118
GluN2A Antagonist
JNJ-78911118 is a selective GluN2A antagonist that operates as a negative allosteric modulator (NAM), effectively suppressing glutamate efficacy and decreasing glycine potency at GluN1/2A receptors. With an IC50 of 44 nM and over 200-fold selectivity against GluN1/2B, 2C, and 2D receptors, it is a potent compound suitable for neuropharmacology studies. The compound demonstrates significant pharmacodynamic effects in vivo, making it valuable for research into depression and associated neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3106013-91-3 |
| Applications | GluN2A Antagonist |
| Formula | C19H16ClF2N5O2 |
| Molecular Weight | 419.81 |
| SMILES | CC1=NC(C(NCC2=CC=CN=C2)=O)=CN=C1OCC(F)(F)C3=CC(Cl)=CC=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.