Fig. 1 · Structure
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JNJ-9676
Sarbecovirus Inhibitor
JNJ-9676 is an orally active inhibitor targeting the M protein of Sarbecoviruses, specifically designed to impede viral replication. By binding to the M protein dimer, it induces a conformational change, creating a compound-induced binding pocket. This compound exhibits potent in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV, and various Sarbecovirus strains originating from bats and pangolins, making it a valuable tool for research in coronavirus inhibition and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3026520-19-1 |
| Applications | Sarbecovirus Inhibitor |
| Formula | C28H21F2N5O2 |
| Molecular Weight | 497.50 |
| SMILES | N#CC1=CC=CC(NC(C2=C3N(N=C2)C[C@@H](N(C4=CC=C(C=C4)C(F)(C5=CC=CC=C5)F)C3=O)C)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.