Fig. 1 · Structure
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Jolkinolide A
VEGF Inhibitor
Jolkinolide A is a diterpenoid compound that functions as a vascular endothelial growth factor (VEGF) inhibitor. This compound demonstrates significant anti-tumor activity by disrupting angiogenesis in tumor tissues. Jolkinolide A effectively inhibits the Akt-STAT3-mTOR signaling pathway, leading to reduced expression of VEGF in A549 cells. It is a valuable reagent for research applications focusing on cancer biology and therapeutic interventions targeting tumor vascularization.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 37905-07-0 |
| Applications | VEGF Inhibitor |
| Formula | C20H26O3 |
| Molecular Weight | 314.42 |
| SMILES | CC1=C2[C@H]3O[C@]3([C@H]4C=C2OC1=O)CC[C@H]5[C@]4(CCCC5(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.