JPC-3210 is an orally active aminomethylphenol that targets the hemoglobin digestion pathway in malaria parasites. Exhibiting significant anti-malarial activity, it has a mean IC50 ranging from 2.5 to 19 nM and demonstrates inhibitory effects on CYP2D6 and CYP3A4 isozymes. In vivo studies show that JPC-3210 effectively suppresses P. berghei infection in mice and offers prophylactic protection. This compound is suitable for research on malaria prevention strategies and the exploration of mechanisms in anti-malarial drug development.
JPC-3210 is an orally active aminomethylphenol that targets the hemoglobin digestion pathway in malaria parasites. Exhibiting significant anti-malarial activity, it has a mean IC50 ranging from 2.5 to 19 nM and demonstrates inhibitory effects on CYP2D6 and CYP3A4 isozymes. In vivo studies show that JPC-3210 effectively suppresses P. berghei infection in mice and offers prophylactic protection. This compound is suitable for research on malaria prevention strategies and the exploration of mechanisms in anti-malarial drug development.
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