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JPHM-2-167

PHD Inhibitor

JPHM-2-167 is a selective inhibitor of prolyl hydroxylase domain enzymes (PHDs), specifically targeting PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. This compound demonstrates potential in modulating hypoxia-inducible factor (HIF) pathways, making it valuable for research applications related to chronic kidney disease and other hypoxia-related conditions. JPHM-2-167’s specificity and efficacy suggest its utility in elucidating the role of PHD inhibition in cellular responses to oxygen availability.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1258877-17-6
Applications	PHD Inhibitor
Formula	C₃₀H₂₈N₆O₂
Molecular Weight	504.58
SMILES	O=C(N(C1=CC=C(C2=CC=CC=C2)C=C1)C(N3C4=NC=CC=N4)=O)C3(CC5)CCN5CC6=NC=CC=C6C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.