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JR4-187

Anticancer Agent

JR4-187 is an orally active, copper-dependent anticancer agent that targets multiple pathways to exert its biological effects. It downregulates genes associated with oxidative phosphorylation and MYC and E2F targets while upregulating tumor necrosis factor alpha (TNF-α), p53, and KRAS signaling pathways, leading to increased reactive oxygen species (ROS) production and apoptosis. This compound demonstrates selective cytotoxicity against KRAS-mutant cancer cells and shows promise in mouse models of pancreatic cancer. JR4-187 is suitable for research applications in various cancer types, including pancreatic ductal adenocarcinoma, colon cancer, and rectal cancer.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2446965-01-9
Applications	Anticancer Agent
Formula	C₂₃H₂₅FN₆O₂
Molecular Weight	436.48
SMILES	O=C(NC1=C2N=CC=CC2=CC(F)=C1)C3=CN=C(N(CC4)CCC4([C@@H]5N)CO[C@H]5C)C=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.