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Fig. 1 · Structure
Cat. No.
A22164
CAS No.
2247481-21-4
Formula
C24H33ClN6O2S
Mol. Weight
505.08

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JSH-150

CDK9 inhibitor

JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A-375 GI50 0.044 μM Antiproliferative activity against human A375 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
A-431 GI50 0.019 μM Antiproliferative activity against human A431 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
CHO GI50 1.1 μM Antiproliferative activity against CHO cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
COLO 205 GI50 0.014 μM Antiproliferative activity against human COLO205 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
GISTT1 GI50 0.0021 μM Antiproliferative activity against human GISTT1 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
HL-60 GI50 0.056 μM Antiproliferative activity against human HL60 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
MOLM-13 GI50 0.012 μM Antiproliferative activity against human MOLM13 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
MOLM-14 GI50 0.0011 μM Antiproliferative activity against human MOLM14 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
MV4-11 GI50 0.012 μM Antiproliferative activity against human MV4-11 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
OCI-AML-3 GI50 0.0066 μM Antiproliferative activity against human OCI-AML3 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
Ramos GI50 0.013 μM Antiproliferative activity against human Ramos cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
SKM-1 GI50 0.012 μM Antiproliferative activity against human SKM1 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
SK-N-BE(2)-M17 GI50 0.034 μM Antiproliferative activity against human BE(2)-M17 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]
U-937 GI50 0.002 μM Antiproliferative activity against human U937 cells after 72 hrs by Celltiter-Glo assay [PMID: 30253346]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2247481-21-4
Applications CDK9 inhibitor
Formula C24H33ClN6O2S
Molecular Weight 505.08
SMILES
COCCN[C@@H]1CC[C@@H](NC2=NC=C(Cl)C(C3=CSC(NCC4(C#N)CCOCC4)=N3)=C2)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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