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Fig. 1 · Structure
Cat. No.
A59768
CAS No.
357330-77-9
Formula
C20H25Cl2N3O5S
Mol. Weight
490.40

Documents & Downloads

JTC-017

Corticotropin-releasing Hormone Receptor 1 Antagonist

JTC-017 is a selective antagonist of the corticotropin-releasing hormone receptor 1. It effectively reduces hippocampal noradrenaline release, mitigates visceral perception, and decreases levels of adrenocorticotropic hormone, contributing to anxiety reduction after acute colorectal distention in rodent models. This compound is utilized in research to investigate stress-related alterations in colonic motility and has implications for studying anxiety and gastrointestinal disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 357330-77-9
Applications Corticotropin-releasing Hormone Receptor 1 Antagonist
Formula C20H25Cl2N3O5S
Molecular Weight 490.40
SMILES
O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC(S(=O)(N(CC)CC)=O)=CC(N(C)C)=C2OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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