Fig. 1 · Structure
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JTP-103237
MGAT2 Inhibitor
JTP-103237 is a selective inhibitor of the MGAT2 enzyme, exhibiting an IC50 of 0.019 μM for human MGAT2 and 6.423 μM for human MGAT3. This compound effectively modulates fat absorption, reduces plasma glucose levels, and serves as a preventative agent against diet-induced obesity. JTP-103237 is valuable for research in metabolic disorders and obesity-related studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1883864-16-1 |
| Applications | MGAT2 Inhibitor |
| Formula | C24H29F3N6O |
| Molecular Weight | 474.52 |
| SMILES | FC(F)(F)OC1=CC=C(C2=NN=C3CN(C4=NC(C(C)(C)C)=CC(C(C)(C)C)=N4)CCN32)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.