Biological Activity
JTT-705 (Dalcetrapib) is a CETP inhibitor.Inhibition of CETP is a target to increase HDL-cholesterol and potentially reduce atherosclerosis.
Targets
rhCETP | ||||
0.2 μM |
In vitro (25°C) | DMSO | 66 mg/mL (169.41 mM) | |
Water | Insoluble | ||
Ethanol | 66 mg/mL (169.41 mM) | ||
In vivo | 0.5% methylcellulose | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.67 mL | 128.34 mL | 256.67 mL |
0.5 mM | 5.13 mL | 25.67 mL | 51.33 mL |
1 mM | 2.57 mL | 12.83 mL | 25.67 mL |
5 mM | 0.51 mL | 2.57 mL | 5.13 mL |
*The above data is based on the productmolecular weight 389.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11213 |
---|---|
Actions | Inhibitor |
CAS No. | 211513-37-0 |
Formula | C23H35NO2S |
M. Wt | 389.6 |
Purity | >98% |
Synonyms | JTT705 |
SMILES | CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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