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JTT251

PDHK Inhibitor

JTT251 is a selective inhibitor of pyruvate dehydrogenase kinase (PDHK), targeting the allosteric lipoamide-binding domain. This compound induces partial inhibition of PDHK enzymatic activity, which is essential for metabolic regulation. JTT251 is valuable for research applications focused on cancer metabolism and therapeutic interventions aimed at modulating PDHK activity in oncological studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1627957-25-8
Applications	PDHK Inhibitor
Formula	C₂₆H₂₈F₃N₃O₄
Molecular Weight	503.51
SMILES	FC(F)([C@@]1(C2=CC(OCCC(C)(O)C)=CC(C3=CN(N=C3)C(C)(C)C(N)=O)=C2C4=CC=CC=C41)O)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.