JY-XHe-053 is a selective agonist of GABAA receptors, particularly targeting those containing the α5 subunit, with an affinity of 0.7 nM. This compound demonstrates significant biological activity at GABAA receptors, particularly at the α2 and α3 subunits. Despite its potency, JY-XHe-053 exhibits minimal anti-anxiety activity, making it a valuable tool for investigating GABAA receptor function and the role of the α5 subunit in neurological research.
JY-XHe-053 is a selective agonist of GABAA receptors, particularly targeting those containing the α5 subunit, with an affinity of 0.7 nM. This compound demonstrates significant biological activity at GABAA receptors, particularly at the α2 and α3 subunits. Despite its potency, JY-XHe-053 exhibits minimal anti-anxiety activity, making it a valuable tool for investigating GABAA receptor function and the role of the α5 subunit in neurological research.
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