Fig. 1 · Structure
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JY-XHe-053
GABAA receptors agonist
JY-XHe-053 is a selective agonist of GABAA receptors, particularly targeting those containing the α5 subunit, with an affinity of 0.7 nM. This compound demonstrates significant biological activity at GABAA receptors, particularly at the α2 and α3 subunits. Despite its potency, JY-XHe-053 exhibits minimal anti-anxiety activity, making it a valuable tool for investigating GABAA receptor function and the role of the α5 subunit in neurological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 612526-36-0 |
| Applications | GABAA receptors agonist |
| Formula | C22H16FN3O2 |
| Molecular Weight | 373.38 |
| SMILES | O=C(OCC)C1=C2CN=C(C3=CC(C#C)=CC=C3N2C=N1)C4=CC=CC=C4F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.