Fig. 1 · Structure
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Kartogenin sodium
Chondroid Tissue Inducer
Kartogenin sodium is a chondroid tissue inducer that facilitates chondrogenic tissue formation with an EC50 of 100 nM. It operates by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. This compound not only promotes cartilage repair but also enhances tendon-bone junction wound healing through increased collagen synthesis. Kartogenin sodium is utilized in research concerning cartilage regeneration, tendon-bone healing, and osteoarthritis, as well as in various applications in regenerative medicine and limb development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 1401168-39-5 |
| Applications | Chondroid Tissue Inducer |
| Formula | C20H14NNaO3 |
| Molecular Weight | 339.32 |
| Synonyms | KGN sodium |
| SMILES | O=C(O[Na])C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.