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KB R6933

5-HT3 Receptor Antagonist

KB R6933 is a potent and selective antagonist of the 5-HT3 receptor, known for its oral bioactivity. This compound effectively inhibits serotonin-induced diarrhea but does not affect diarrhea triggered by castor oil or prostaglandin E2. Additionally, KB R6933 has been shown to mitigate bradycardia induced by serotonin, making it a valuable tool for research in gastrointestinal pharmacology and cardiovascular studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	148565-09-7
Applications	5-HT3 Receptor Antagonist
Formula	C₂₃H₃₀ClN₅O₈
Molecular Weight	539.97
Synonyms	KB 6806 maleate
SMILES	OC(/C=C\C(O)=O)=O.CC(N1C(N2CCN(CC2)C)=NC3=CC(Cl)=C(N)C=C31)C.OC(/C=C\C(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.