Fig. 1 · Structure
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(+)-KCC2 blocker 1 (d-KCC2 blocker 1)
KCC2 Blocker
(+)-KCC2 blocker 1 is a selective inhibitor of the K+-Cl- cotransporter KCC2, exhibiting an IC50 value of 0.4 μM. This compound, a benzyl prolinate, serves as an enantiomer of KCC2 blocker 1 and is useful in research focused on chloride homeostasis and synaptic transmission. Applications include the investigation of neurological disorders and conditions involving altered inhibitory neurotransmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1228439-71-1 |
| Applications | KCC2 Blocker |
| Formula | C22H25NO5S |
| Molecular Weight | 415.50 |
| Synonyms | d-KCC2 blocker 1 |
| SMILES | O=C(OCC1=CC=CC=C1)C2(CC3=CC=C(S(=O)(C)=O)C=C3)N(C(C)=O)CCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.