Fig. 1 · Structure
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(-)-KCC2 blocker 1 (l-KCC2 Blocker 1)
Enantiomer of KCC2 blocker 1
(-)-KCC2 blocker 1 is an enantiomer of KCC2 blocker 1, targeting the K+-Cl- cotransporter KCC2. This compound exhibits selective inhibition with an IC50 of 1 μM, demonstrating its effectiveness in modulating chloride transport. It is valuable in research related to neuronal excitability and synaptic transmission, making it a useful tool for investigating neurological disorders and transport mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 1228439-73-3 |
| Applications | Enantiomer of KCC2 blocker 1 |
| Formula | C22H25NO5S |
| Molecular Weight | 415.50 |
| SMILES | O=C(OCC1=CC=CC=C1)C2(CC3=CC=C(S(=O)(C)=O)C=C3)N(C(C)=O)CCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.