KD6001 is a humanized IgG1κ monoclonal antibody that targets CTLA-4, effectively disrupting the interactions between CTLA-4 and its ligands CD80 and CD86, with an IC50 of 16 ng/mL. This antibody promotes the activation of T cells by enhancing the expression of IL-2 and IFNγ in PHA-activated human lymphocytes. KD6001 demonstrates significant antitumor activity, inhibiting tumor growth in various mouse models, including MC38, B16, and Hepa1-6. It is relevant for research applications in cancer, particularly in advanced melanoma, hepatocellular carcinoma, and liver cancer.
KD6001 is a humanized IgG1κ monoclonal antibody that targets CTLA-4, effectively disrupting the interactions between CTLA-4 and its ligands CD80 and CD86, with an IC50 of 16 ng/mL. This antibody promotes the activation of T cells by enhancing the expression of IL-2 and IFNγ in PHA-activated human lymphocytes. KD6001 demonstrates significant antitumor activity, inhibiting tumor growth in various mouse models, including MC38, B16, and Hepa1-6. It is relevant for research applications in cancer, particularly in advanced melanoma, hepatocellular carcinoma, and liver cancer.
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