Documents & Downloads

KDX1381

CK2α Inhibitor

KDX1381 is a bivalent inhibitor of CK2α, exhibiting an IC50 of 17 nM and a KD of 54 nM. This compound demonstrates significant antitumor activity in mouse models, including 786-O and A375 tumor xenografts. Furthermore, KDX1381 enhances the efficacy of VEGFR inhibitors and DNA-damaging agents in mouse models of hepatocellular carcinoma and glioma, making it a valuable tool for cancer research and therapeutic exploration.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2757728-47-3
Applications	CK2α Inhibitor
Formula	C₃₂H₃₂F₂N₆O₄S
Molecular Weight	634.70
SMILES	FC1=CC=CC(O)=C1C2=CC=C(S(NCCN3CCC(CN4C=C(C5=C(C(C)=O)NC6=C5C=C(F)C=C6)N=N4)CC3)(=O)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.