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Keliximab
Keliximab (SB-210396) is a chimeric human/macaque IgG1 monoclonal antibody targeting CD4 with a dissociation constant (Ki) of 1.0 nM for soluble CD4. This antibody effectively blocks T-cell proliferation and inhibits the production of interleukin-2 (IL-2), mechanisms critical in the immune response. Due to its specific action on T-cells, Keliximab is extensively utilized in oncological research to study the modulation of the immune system in the tumor microenvironment.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 174722-30-6 |
| Synonyms | SB-210396; IDEC CE9.1 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.