Fig. 1 · Structure
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KH-4-43
E3 CRL4 Inhibitor
KH-4-43 is a potent inhibitor of the E3 ubiquitin ligase complex CRL4. It effectively disrupts the core ligase activity, demonstrating significant anticancer properties. KH-4-43 exhibits binding affinities with E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD, with Kd values of 83 nM and 9.4 µM, respectively, making it a valuable tool for exploring mechanisms of protein degradation and cancer biology. This compound holds promise for research applications in targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2813310-07-3 |
| Applications | E3 CRL4 Inhibitor |
| Formula | C19H10ClF3N2O4 |
| Molecular Weight | 422.74 |
| SMILES | O=C1C2=CC=C(C(O)=C2OC(C(F)(F)F)=C1C3=CN(C4=CC=C(C=C4)Cl)N=C3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.