Fig. 1 · Structure
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KHK-IN-1
Ketohexokinase Inhibitor
KHK-IN-1 is a selective inhibitor of ketohexokinase (KHK), exhibiting an IC50 of 12 nM and a membrane permeability suitable for cellular applications. It effectively reduces the production of fructose-1-phosphate (F1P) in HepG2 cell lysates, with an inhibition threshold greater than 400 nM. This compound offers valuable insights for research focused on the pathophysiology of diabetes and obesity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1303469-70-6 |
| Applications | Ketohexokinase Inhibitor |
| Formula | C21H26N8S |
| Molecular Weight | 422.55 |
| SMILES | CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.