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VEGFR-2 inhibitor

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Catalog No. A10502

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ki8751 5mg A10502-5

Regular Price: €47.50

Special Price: €42.75

Ki8751 10mg A10502-10

Regular Price: €71.25

Special Price: €64.13

Ki8751 50mg A10502-50

Regular Price: €285.00

Special Price: €256.50

Ki8751 100mg A10502-100

Regular Price: €475.00

Special Price: €427.50

Ki8751 10mM * 1mL in DMSO A10502-10mM-D

Regular Price: €76.00

Special Price: €68.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.


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Publications citing Adooq Products
Ki8751 Citations (1)
  • Kohei Ashina, .et al. VEGF-induced blood flow increase causes vascular hyper-permeability in vivo, Biochem Biophys Res Commun, 2015, Aug 21;464(2):590-5 PMID: 26163262

Chemical Information

Catalog Num A10502
Actions Inhibitor
M. Wt 469.4
Formula C24H18F3N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 228559-41-9
Synonyms Ki-8751

Biological Activity

Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.
Target Value
VEGFR2IC50: 0.9nM
c-KitIC50: 40nM
PDGFRαIC50: 67nM
FGFR2IC50: 170nM
EGFRIC50: >10μM
HGFRIC50: >10μM
Insulin ReceptorIC50: >10μM


Solubility (25°C)* In vitro DMSO 47 mg/mL (100.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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