Fig. 1 · Structure
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Kibdelone C
Anticancer Agent
Kibdelone C is a hexacyclic tetrahydroxanthone that functions as an anticancer agent, demonstrating sub-nanomolar GI50 activity against human SR leukemia and SN12C renal carcinoma cell lines. This compound disrupts the actin cytoskeleton in cancer cells, inducing cell contraction and the formation of actin stress fibers; notably, it does so without direct interactions with actin, topoisomerase inhibition, or DNA binding. Kibdelone C serves as a valuable tool in cancer research, particularly in studies focused on leukemia and renal cell carcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 934464-79-6 |
| Applications | Anticancer Agent |
| Formula | C29H28ClNO10 |
| Molecular Weight | 585.99 |
| SMILES | OC1=C2C3=C(O)C(C(N(C(CCC)=C4Cl)C)=O)=C4C(O)=C3CCC2=C(C5=C1C(C6=C([C@H](C[C@@H]([C@@H]6O)O)O)O5)=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.