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KIM-161

PIK3CA Inhibitor

KIM-161 is a selective inhibitor of the PIK3CA pathway, demonstrating potent antiproliferative effects with IC50 values of 1.428 µM and 1.562 µM against PI3KCA mutant breast cancer cell lines MCF7 and T47D, respectively. This compound induces apoptosis and cell cycle arrest through the inhibition of the PI3K/AKT/mTOR signaling cascade while also promoting reactive oxygen species (ROS) production. KIM-161 is a valuable tool for investigating breast cancer, particularly in the context of PIK3CA mutations and their therapeutic implications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2559686-28-9
Applications	PIK3CA Inhibitor
Formula	C₂₇H₂₅N₃O₃
Molecular Weight	439.51
SMILES	O=C(NCC1=CC=CC=C1)CC2=CC=C(N3C(/C(N=C3C)=C/C4=CC=C(OC)C=C4)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.