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Biological Activity
KL-1 is an inhibitor of SEC and transcription elongation by Pol II which disrupts the cyclin T1-AFF4 interaction within SEC, and attenuates SEC-dependent rapid transcriptional responses. KL-1 inhibits MYC transcriptional programs.
| In vitro | DMSO | 64 mg/mL (185.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.92 mL | 144.6 mL | 289.2 mL |
| 0.5 mM | 5.78 mL | 28.92 mL | 57.84 mL |
| 1 mM | 2.89 mL | 14.46 mL | 28.92 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.78 mL |
*The above data is based on the productmolecular weight 345.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18418 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 900308-84-1 |
| Formula | C18H16ClNO4 |
| M. Wt | 345.78 |
| Purity | >98% |
| Synonyms | KL1; KL 1; KL-1 |
| SMILES | O=C(NC1=CC(Cl)=CC=C1C)C(CC(C2=CC=CC(OC)=C2)=O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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