Fig. 1 · Structure
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KL-11743
GLUT1-4 Inhibitor
KL-11743 is a potent, orally active inhibitor of class I glucose transporters, exhibiting IC50 values of 115 nM for GLUT1, 137 nM for GLUT2, 90 nM for GLUT3, and 68 nM for GLUT4. This glucose-competitive inhibitor effectively disrupts glucose metabolism and demonstrates potential for synergistic effects with electron transport inhibitors, inducing cell death. Additionally, KL-11743 promotes the formation of disulfide bonds in actin cytoskeletal proteins, leading to a unique form of cellular disulfidptosis. It is a valuable tool for research applications involving metabolic regulation and cell death mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1369452-53-8 |
| Applications | GLUT1-4 Inhibitor |
| Formula | C30H30N6O3 |
| Molecular Weight | 522.60 |
| SMILES | O=C(COC1=CC=CC(C2=NC(NC3=CC=C(C4=CNN=C4)C=C3)=C5C=C(OCC)C=CC5=N2)=C1)NC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.