Fig. 1 · Structure
Documents & Downloads
KL-50
Toxin
KL-50 is a selective toxin that targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which is responsible for reversing the formation of O6-alkylguanine lesions. It activates DNA damage response pathways and induces cell cycle arrest in MGMT-lacking cells, functioning independently of mismatch repair (MMR) mechanisms. KL-50 is a valuable tool for research focused on brain tumors with deficient MGMT expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1161826-19-2 |
| Applications | Toxin |
| Formula | C7H7FN6O2 |
| Molecular Weight | 226.17 |
| SMILES | O=C(C(N=CN12)=C2N=NN(CCF)C1=O)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.