Fig. 1 · Structure
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KL044
Cryptochrome Stabilizer
KL044 is a potent stabilizer of the clock protein cryptochrome (CRY), exhibiting a pEC50 value of 7.32. This compound effectively extends the circadian period and represses Per2 activity, making it a valuable tool for studying circadian rhythms and their regulatory mechanisms. Its applications span circadian biology research, enabling investigations into sleep disorders, metabolic processes, and related physiological functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Stabilizer |
| CAS Number | 1801856-93-8 |
| Applications | Cryptochrome Stabilizer |
| Formula | C21H14ClN3O |
| Molecular Weight | 359.81 |
| SMILES | O=C(CN1C2=C(C=CC=C2)C3=C1C=CC=C3)NC4=C(C=CC=C4Cl)C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.