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Form	MW
KL1333 hydrochloride This page	276.72
KL1333	240.262

KL1333 hydrochloride

NAD+ Modulator

KL1333 hydrochloride is an orally bioavailable NAD+ modulator that acts as a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1), resulting in elevated intracellular NAD+ levels through the process of NADH oxidation. This enhancement of NAD+ promotes the activation of SIRT1 and AMPK, which in turn stimulates PGC-1α activity. KL1333 hydrochloride shows potential in improving energy metabolism and addressing mitochondrial dysfunction in conditions such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Additionally, it has demonstrated protective effects against cisplatin-induced ototoxicity in mouse cochlear cultures.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1800406-26-1
Applications	NAD+ Modulator
Formula	C₁₄H₁₃ClN₂O₂
Molecular Weight	276.72
SMILES	O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.