Fig. 1 · Structure
Documents & Downloads
KMG-1068
Molecular Glue/GSPT1/2 Degrader
KMG-1068 is a molecular glue that targets GSPT1/2 for degradation. By binding to the IMiD binding site on cereblon (CRBN), KMG-1068 facilitates the formation of a ternary complex, leading to CRBN-dependent degradation of GSPT1/2. This compound holds significant potential for cancer research applications, providing insights into the roles of GSPT1/2 in tumorigenesis.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3113750-79-8 |
| Applications | Molecular Glue/GSPT1/2 Degrader |
| Formula | C21H22N4O4S |
| Molecular Weight | 426.49 |
| SMILES | O=C1C(C)=C(C)N=CN1CC(NC2=NC(C(OC)=O)=C(CCC3=CC=CC=C3)S2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.