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KNa1.1-IN-2

KNa1.1 Channel Inhibitor

KNa1.1-IN-2 is a selective inhibitor of the KNa1.1 channel, specifically designed to block channel activity associated with Gain-of-function mutations. It demonstrates high efficacy against the hERG channel and effectively inhibits the mutant Y796H. This compound is particularly relevant for research into KCNT1-related epilepsy, offering potential insights into therapeutic interventions for this condition. Its ability to penetrate the blood-brain barrier further enhances its applicability in neurological studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3037315-44-6
Applications	KNa1.1 Channel Inhibitor
Formula	C₂₄H₂₇NO
Molecular Weight	345.48
SMILES	C1(OCC2=CC=CC=C2)=C(CCC3CCNCC3)C4=C(C=CC=C4)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.