KNK437

Catalog No.: A14389

pan-HSP inhibitor

KNK437

KNK437 Chemical Structure

CAS NO. 218924-25-5

KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.

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10 mg
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50 mg
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Biological Activity

KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
Targets
HSP105 HSP72 HSP40
In vitro (25°C) DMSO Warmed: 14 mg/mL (57.08 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.78 mL 203.89 mL 407.78 mL
0.5 mM 8.16 mL 40.78 mL 81.56 mL
1 mM 4.08 mL 20.39 mL 40.78 mL
5 mM 0.82 mL 4.08 mL 8.16 mL

*The above data is based on the productmolecular weight 245.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14389
Actions Inhibitor
CAS No. 218924-25-5
Formula C13H11NO4
M. Wt 245.23
Purity >98%
Synonyms KNK-437, KNK 437
SMILES O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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