KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
Targets
Target
Value
Product Information
Catalog Num
A14389
Formula
C13H11NO4
Molecular Weight
245.23
CAS Number
218924-25-5
SMILES
O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
Synonyms
KNK-437, KNK 437
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
Warmed: 14 mg/mL (57.08 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
5% DMSO+corn oil
1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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