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$0.00 Biological Activity
KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
Targets
| HSP105 | HSP72 | HSP40 | ||
| In vitro (25°C) | DMSO | Warmed: 14 mg/mL (57.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+corn oil | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.78 mL | 203.89 mL | 407.78 mL |
| 0.5 mM | 8.16 mL | 40.78 mL | 81.56 mL |
| 1 mM | 4.08 mL | 20.39 mL | 40.78 mL |
| 5 mM | 0.82 mL | 4.08 mL | 8.16 mL |
*The above data is based on the productmolecular weight 245.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14389 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 218924-25-5 |
| Formula | C13H11NO4 |
| M. Wt | 245.23 |
| Purity | >98% |
| Synonyms | KNK-437, KNK 437 |
| SMILES | O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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