Fig. 1 · Structure
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KP-2067
CaSR Agonist
KP-2067 is a calcium-sensing receptor (CaSR) agonist peptide known for its role in activating CaSR pathways. It demonstrates dose-dependent activation of CaSR in HEK293T cells that overexpress human CaSR, with an EC50 value of 18.4 μM. In research applications, KP-2067 has been shown to significantly decrease plasma parathyroid hormone levels in rat models, providing a valuable tool for studies related to calcium regulation and bone metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1262781-19-0 |
| Applications | CaSR Agonist |
| Formula | C35H68N20O8S |
| Molecular Weight | 929.11 |
| SMILES | N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@@H](CS)NC(C)=O)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.