Selinexor (KPT-330)

Catalog No.: A12582

CRM1 inhibitor

Selinexor (KPT-330)

Selinexor (KPT-330) Chemical Structure

CAS NO. 1393477-72-9

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$112.00
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Biological Activity

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
Targets
CRM1 (Cell-free assay)
In vitro (25°C) DMSO 78 mg/mL (175.94 mM)
Water Insoluble
Ethanol 36 mg/mL (81.21 mM)
In vivo 2% DMSO+40%PEG 300+5% Tween80 +ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.56 mL 112.79 mL 225.58 mL
0.5 mM 4.51 mL 22.56 mL 45.12 mL
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12582
Actions Inhibitor
CAS No. 1393477-72-9
Formula C17H11F6N7O
M. Wt 443.31
Purity >98%
Synonyms KPT330, KPT 330
SMILES C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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