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KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
Targets
| CRM1 (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 78 mg/mL (175.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 36 mg/mL (81.21 mM) | ||
| In vivo | 2% DMSO+40%PEG 300+5% Tween80 +ddH2O | 3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.56 mL | 112.79 mL | 225.58 mL |
| 0.5 mM | 4.51 mL | 22.56 mL | 45.12 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.56 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12582 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1393477-72-9 |
| Formula | C17H11F6N7O |
| M. Wt | 443.31 |
| Purity | >98% |
| Synonyms | KPT330, KPT 330 |
| SMILES | C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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