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CRM1 inhibitor

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Catalog No. A12582

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KPT-330 5mg A12582-5

Regular Price: $60.00

Special Price: $54.00

KPT-330 10mg A12582-10

Regular Price: $100.00

Special Price: $90.00

KPT-330 25mg A12582-25

Regular Price: $200.00

Special Price: $180.00

KPT-330 50mg A12582-50

Regular Price: $350.00

Special Price: $315.00

KPT-330 10mM * 1mL in DMSO A12582-10mM-D

Regular Price: $112.00

Special Price: $100.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.


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Chemical Information

Catalog Num A12582
Actions Inhibitor
M. Wt 443.31
Formula C17H11F6N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1393477-72-9
Synonyms KPT330, KPT 330
SMILES C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

Biological Activity

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
CRM1 (Cell-free assay)


Solubility (25°C)* In vitro DMSO 89 mg/mL (200.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 40 mg/mL (90.23 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.56 mL 112.79 mL 225.58mL
0.5 mM 4.51 mL 22.56 mL 45.12 mL
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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