KPT-6566

Catalog No.: A19126

prolyl isomerase PIN1 inhibitor

KPT-6566

KPT-6566 Chemical Structure

CAS NO. 881487-77-0

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.

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Package Price Qty
1 mg
$100.00
5 mg
$320.00
10 mg
$520.00
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Biological Activity

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.73 mL 225.46 mL
0.5 mM 4.51 mL 22.55 mL 45.09 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19126
Actions Inhibitor
M. Wt 443.54
Formula C22H21NO5S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 881487-77-0
Synonyms KPT 6566; KPT6566
SMILES O=C(O)CSC(C1=O)=C/C(C2=C1C=CC=C2)=N\S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O

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