Fig. 1 · Structure
Documents & Downloads
KR-31080
Angiotensin II Receptor Inhibitor
KR-31080 is an imidazo[4,5-b]pyridine derivative that acts as a potent angiotensin II receptor inhibitor. It exhibits significant biological activity by reducing nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells, demonstrating an 8.3% inhibition at a concentration of 2 μM. This compound is valuable for research applications aimed at understanding the role of angiotensin II signaling in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 174800-22-7 |
| Applications | Angiotensin II Receptor Inhibitor |
| Formula | C30H28N8O |
| Molecular Weight | 516.60 |
| Synonyms | SK-1080 |
| SMILES | O=N1=C(C2=CC3=C(N=C2C)N(CC4=CC=C(C5=C(C6=NN=NN6)C=CC=C5)C=C4)C(CCCC)=N3)C=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.