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KR31173

AT1 Antagonist

KR31173 is a selective antagonist of the angiotensin II type 1 receptor (AT1) with an IC50 of 3.27 nM. This compound has potential applications in imaging studies as a positron emission tomography (PET) tracer when labeled with the carbon-11 isotope. In preclinical studies using CD-1 mice, KR31173 demonstrates favorable biodistribution and pharmacological characteristics, selectively targeting organs with a high density of AT1 receptors. This makes it a valuable tool for research into cardiovascular and metabolic diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	260554-07-2
Applications	AT1 Antagonist
Formula	C₃₁H₃₀N₈O₂
Molecular Weight	546.62
SMILES	[O-][N+]1=CC=CC=C1C2=C(COC)N=C(N(CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C(CCCC)=N6)C6=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.