KRAS G12C degrader-1 is a potent degrader targeting the KRAS G12C mutation, exhibiting a DC50 of less than 100 nM. This compound functions as a chaperone-mediated protein degrader (CHAMP), leveraging HSP90 to promote the degradation of KRAS G12C. It is invaluable for cancer research, particularly in studies aimed at delineating the impact of KRAS mutations on tumorigenesis and therapeutic resistance.
KRAS G12C degrader-1 is a potent degrader targeting the KRAS G12C mutation, exhibiting a DC50 of less than 100 nM. This compound functions as a chaperone-mediated protein degrader (CHAMP), leveraging HSP90 to promote the degradation of KRAS G12C. It is invaluable for cancer research, particularly in studies aimed at delineating the impact of KRAS mutations on tumorigenesis and therapeutic resistance.
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