Fig. 1 · Structure
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KRAS G12C inhibitor 45
KRAS G12C Inhibitor
KRAS G12C inhibitor 45 is a selective inhibitor that targets the KRAS G12C mutation, which plays a crucial role in various cancers. This compound demonstrates significant biological activity by inhibiting the downstream signaling pathways associated with KRAS G12C, thereby inducing apoptosis in tumor cells harboring this mutation. It is a valuable tool for cancer research, particularly in studies focusing on personalized medicine and targeted therapies for KRAS G12C-positive tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2670380-74-0 |
| Applications | KRAS G12C Inhibitor |
| Formula | C32H33F2N5O5S |
| Molecular Weight | 637.70 |
| SMILES | O=C1N(C2=C(C=CC=C2C(C)C)S(C)(=O)=O)C3=NC(C4=C(C=CC=C4O)F)=C(F)C=C3C(N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.