Fig. 1 · Structure
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KRAS G12C inhibitor 67
KRAS G12C Inhibitor
KRAS G12C Inhibitor 67 is an orally bioavailable compound that selectively targets the KRAS G12C mutant. It effectively inhibits phosphorylated ERK (pERK) and active KRAS, leading to reduced proliferation in various tumor cell lines harboring the KRAS G12C mutation. This inhibitor demonstrates significant anticancer activity against several types of malignancies, including esophageal, bladder, colorectal, lung, and pancreatic cancers, making it a valuable tool for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2649788-46-3 |
| Applications | KRAS G12C Inhibitor |
| Formula | C25H19ClF2N4O3S |
| Molecular Weight | 528.96 |
| SMILES | N#CC1=C(N)SC2=C(F)C=CC(C3=C(F)C=C(C(N4[C@@](CN(CC4)C(C=C)=O)([H])CCO5)=O)C5=C3Cl)=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.