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KRAS-IN-5

KRAS Inhibitor

KRAS-IN-5 is a selective inhibitor targeting KRAS mutants, including KRASG12D and KRASG12V, with a GNE IC50 value of 1.3 nM against KRASG12D. This compound inhibits KRAS-mediated signaling pathways, effectively blocking tumor cell proliferation by reducing ERK phosphorylation. KRAS-IN-5 exhibits potential for research applications in KRAS mutation-related cancers, including pancreatic, colorectal, and lung cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3082412-00-5
Applications	KRAS Inhibitor
Formula	C₃₅H₃₆F₃N₇O₃
Molecular Weight	659.70
SMILES	FC1=C(CC)C2=C(C=C(NN=C3C)C3=C2C4=C(F)C(N=C(OC[C@@]56CCCN5C[C@H](F)C6)N=C7N(CCCOC8)[C@@H]8CO9)=C7C9=N4)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.