KRAS Inhibitor-14 is a selective inhibitor targeting the KRAS G12C mutation, exhibiting a potent IC50 of 0.249 µM. It effectively inhibits phosphorylated ERK (p-ERK) with IC50 values of 1.12 µM in MIA PaCA-2 cells and >33.3 µM in A549 cells. This compound is valuable for investigating therapeutic strategies in pancreatic, colorectal, and lung cancers.
KRAS Inhibitor-14 is a selective inhibitor targeting the KRAS G12C mutation, exhibiting a potent IC50 of 0.249 µM. It effectively inhibits phosphorylated ERK (p-ERK) with IC50 values of 1.12 µM in MIA PaCA-2 cells and >33.3 µM in A549 cells. This compound is valuable for investigating therapeutic strategies in pancreatic, colorectal, and lung cancers.
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