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KRAS inhibitor-21

Catalog No.: A63756
KRAS Inhibitor
KRAS inhibitor-21 is a potent inhibitor targeting the KRAS G12C mutation with an IC50 value of less than 0.01 μM. This compound demonstrates significant biological activity in attenuating KRAS-mediated signaling pathways, making it a valuable tool for investigating mechanisms of oncogenic transformation. It is particularly useful in cancer research aimed at exploring therapeutic strategies for KRAS-driven malignancies.
KRAS inhibitor-21 2411786-50-8 KRAS Inhibitor
Grouped product items
Size Price Stock Qty
25mg
$1,800.00
In stock
50mg
$2,285.00
In stock
100mg
$2,815.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS inhibitor-21 is a potent inhibitor targeting the KRAS G12C mutation with an IC50 value of less than 0.01 μM. This compound demonstrates significant biological activity in attenuating KRAS-mediated signaling pathways, making it a valuable tool for investigating mechanisms of oncogenic transformation. It is particularly useful in cancer research aimed at exploring therapeutic strategies for KRAS-driven malignancies.
Product Information
Catalog NumA63756
FormulaC33H41N5O3
Molecular Weight555.71
CAS Number2411786-50-8
SMILESC[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=CC(O)=CC6=C5C=CC=C6)C4
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Cell Cycle > Ras