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KRAS inhibitor-26

KRAS G12V Inhibitor

KRAS inhibitor-26 is a potent inhibitor targeting the KRAS G12V mutation, exhibiting an IC50 of ≤100 nM. This compound effectively disrupts oncogenic signaling pathways associated with KRAS, making it a valuable tool for cancer research. Its applications include studies on tumor growth, survival, and potential therapeutic interventions in KRAS-driven malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3030576-80-5
Applications	KRAS G12V Inhibitor
Formula	C₃₆H₃₉F₃N₆O₄
Molecular Weight	676.73
SMILES	FC1=C2C(C3=NC(OC[C@@]45N(CCC5)C[C@@H](C4)F)=N2)=CN=C1C6=C7C(C=CC(F)=C7CCCC(NCCC8([H])CN3CCOC8)=O)=CC(O)=C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.