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KRAS inhibitor-34

Catalog No.: A63757
KRAS Inhibitor
KRAS inhibitor-34 is a selective inhibitor targeting the KRAS protein, exhibiting an IC50 of 6.4 nM. This compound is utilized in tumor research to investigate KRAS-mediated signaling pathways and its role in cancer progression. It provides a valuable tool for studying the therapeutic potential of KRAS inhibition in various malignancies.
KRAS inhibitor-34 3054800-66-4 KRAS Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS inhibitor-34 is a selective inhibitor targeting the KRAS protein, exhibiting an IC50 of 6.4 nM. This compound is utilized in tumor research to investigate KRAS-mediated signaling pathways and its role in cancer progression. It provides a valuable tool for studying the therapeutic potential of KRAS inhibition in various malignancies.
Product Information
Catalog NumA63757
FormulaC42H39F3N6O3
Molecular Weight732.79
CAS Number3054800-66-4
SMILESC#CC1=C(C=CC2=CC(O)=CC(C3=C(C4=C(C(N5CCN(CC5)C(/C(F)=C/C6=CC=CC=N6)=O)=NC(OC[C@@]78CCCN([C@@]7(CCC8)[H])C)=N4)C=C3)F)=C21)F
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Cell Cycle > Ras